Fluralaner Baits Reduce the Infestation of Peromyscus spp. Mice (Rodentia: Cricetidae) by Ixodes scapularis (Acari: Ixodidae) Larvae and Nymphs in a Natural Environment

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creativework.keywords - en

Lyme disease

Borrelia burgdorferi

Ixodes scapularis

Peromyscus

fluralaner

dc.contributor.author

Pelletier, Jérôme

Rocheleau, Jean-Philippe

Aenishaenslin, Cécile

Masson, Gabrielle Dimitri

Lindsay, L. Robbin

Ogden, Nicholas H.

Bouchard, Catherine

Leighton, Patrick A.

dc.date.accessioned

2023-11-28T20:52:51Z

dc.date.available

2023-11-28T20:52:51Z

dc.date.issued

2022-11

dc.description.abstract - en

The development of interventions that reduce Lyme disease incidence remains a challenge. Reservoir-targeted approaches aiming to reduce tick densities or tick infection prevalence with Borrelia burgdorferi have emerged as promising ways to reduce the density of infected ticks. Acaricides of the isoxazoline family offer high potential for reducing infestation of ticks on small mammals as they have high efficacy at killing feeding ticks for a long period. Fluralaner baits were recently demonstrated as effective, in the laboratory, at killing Ixodes scapularis larvae infesting Peromyscus mice, the main reservoir for B. burgdorferi in northeastern North America. Here, effectiveness of this approach for reducing the infestation of small mammals by immature stages of I. scapularis was tested in a natural environment. Two densities of fluralaner baits (2.1 baits/1,000 m2 and 4.4 baits/1,000 m2) were used during three years in forest plots. The number of I. scapularis larvae and nymphs per mouse from treated and control plots were compared. Fluralaner baiting reduced the number of larvae per mouse by 68% (CI95: 51–79%) at 2.1 baits/1,000 m2 and by 86% (CI95: 77–92%) at 4.4 baits/1,000 m2. The number of nymphs per mouse was reduced by 72% (CI95: 22–90%) at 4.4 baits/1,000 m2 but was not significantly reduced at 2.1 baits/1,000 m2. Reduction of Peromyscus mouse infestation by immature stages of I. scapularis supports the hypothesis that an approach targeting reservoirs of B. burgdorferi with isoxazolines has the potential to reduce tick-borne disease risk by decreasing the density of infected ticks in the environment.

dc.identifier.citation

Jérôme Pelletier, Jean-Philippe Rocheleau, Cécile Aenishaenslin, Gabrielle Dimitri Masson, L Robbin Lindsay, Nicholas H Ogden, Catherine Bouchard, Patrick A Leighton, Fluralaner Baits Reduce the Infestation of Peromyscus spp. Mice (Rodentia: Cricetidae) by Ixodes scapularis (Acari: Ixodidae) Larvae and Nymphs in a Natural Environment, Journal of Medical Entomology, Volume 59, Issue 6, November 2022, Pages 2080–2089, https://doi.org/10.1093/jme/tjac106

dc.identifier.doi

https://doi.org/10.1093/jme/tjac106

dc.identifier.issn

1938-2928

dc.identifier.pubmedID

35980603

dc.identifier.uri

https://science-ouverte.canada.ca/handle/123456789/1327

dc.language.iso

en

dc.publisher

Oxford Academic

dc.rights - en

Open Government Licence - Canada

dc.rights - fr

Licence du gouvernement ouvert - Canada

dc.rights.uri - en

https://open.canada.ca/en/open-government-licence-canada

dc.rights.uri - fr

https://ouvert.canada.ca/fr/licence-du-gouvernement-ouvert-canada

dc.subject - en

Health

dc.subject - fr

Santé

dc.subject.en - en

Health

dc.subject.fr - fr

Santé

dc.title - en

Fluralaner Baits Reduce the Infestation of Peromyscus spp. Mice (Rodentia: Cricetidae) by Ixodes scapularis (Acari: Ixodidae) Larvae and Nymphs in a Natural Environment

dc.type - en

Article

dc.type - fr

Article

local.article.journalissue

6

local.article.journaltitle

Journal of Medical Entomology

local.article.journalvolume

59

local.pagination

2080–2089

local.peerreview - en

Yes

local.peerreview - fr

Oui

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